MEDICAL CONDITIONS
Raynaud's Phenomenon
Medical Author: William C. Shiel Jr., MD, FACP, FACR
What is Raynaud's phenomenon?
Raynaud's phenomenon (RP) is a condition resulting in discoloration of the fingers and/or the toes when the patient is exposed to changes in temperature (cold or hot) or emotional events. Skin discoloration occurs because an abnormal spasm of the blood vessels results in a diminished blood supply. Initially, the digit(s) involved turn white because of diminished blood supply. The digit(s) then turn blue because of prolonged lack of oxygen. Finally, the blood vessels reopen, causing a local "flushing" phenomenon, which turns the digit(s) red. This three-phase color sequence (white to blue to red), most often upon exposure to cold temperature, is characteristic of RP. 
Raynaud's phenomenon most frequently affects women, especially in the second, third or fourth decades of life. Persons can have Raynaud's phenomenon alone or as a part of other rheumatic diseases. When it occurs alone it is referred to as "Raynaud's disease" or primary Raynaud's phenomenon. When it accompanies other diseases it is called secondary Raynaud's phenomenon.
What causes Raynaud's phenomenon?
The causes of primary and secondary RP are unknown. Both abnormal nerve control of the blood vessel diameter and nerve sensitivity to cold exposure have been suspected as being contributing factors. The color changes of the digits are in part related to initial blood vessel spasm, followed by dilation, as described above. The small arteries of the digits can have microscopic thickness of their inner lining, which also can lead to abnormal narrowing of the blood vessels.
What conditions have been associated with Raynaud's phenomenon?
Raynaud's phenomenon has been seen with a number of conditions, including rheumatic diseases (scleroderma, rheumatoid arthritis, systemic lupus erythematosus), hormone imbalance (hypothyroidism and carcinoid), trauma (frostbite, vibrating tools), medications (propranolol/Inderal, estrogens without additional progesterone , nicotine, bleomycin used in cancer treatment, and ergotamine used for headaches), and even rarely with cancers.
What are the symptoms of Raynaud's phenomenon?
Symptoms of RP depend on the severity, frequency, and duration of the blood vessel spasm. Most patients with mild disease only notice skin discoloration upon cold exposure. They may also experience mild tingling and numbness of the involved digit(s) that will disappear once the color returns to normal. When the blood vessel spasms become more sustained, the sensory nerves become irritated by the lack of oxygen, and can cause pain in the involved digit(s). Rarely, poor oxygen supply to the tissue can cause the tips of the digits to ulcerate. Ulcerated digits can become infected. With continued lack of oxygen, gangrene of the digits can occur.
Less common areas of the body that can be affected by RP include the nose, ears, and tongue. While these areas rarely develop ulcers, they can be associated with a numbness sensation and pain.
Patients with secondary RP can have symptoms related to their underlying diseases. RP is the initial symptom of 70% of patients with scleroderma, a skin and joint disease. Other rheumatic diseases frequently associated with RP include systemic lupus erythematosus, rheumatoid arthritis, and Sjogren's syndrome. For further information, please read the Systemic Lupus Erythematosus and Rheumatoid Arthritis articles.
How is Raynaud's phenomenon diagnosed?
In patients with the characteristic sequence of skin color changes of the digits upon cold exposure, diagnosing of RP is not difficult. Sometimes, certain patterns in the tiny blood vessels (capillaries) adjacent to the fingernails of patients with RP can be seen using a magnifying viewing instrument. Abnormal nailfold capillary patterns can suggest the possibility of an associated rheumatic condition. There is, however, no single blood test to help the doctor to confirm the diagnosis. The doctor can order certain blood tests (for example, sedimentation rate , rheumatoid factor , antinuclear antibody , thyroid hormone levels, and protein levels) to exclude associated rheumatic diseases. The doctor can also perform certain maneuvers with the patient's extremities to exclude pinched blood vessels that can produce symptoms that mimic RP.
Typically patients with Raynaud's phenomenon that is a manifestation of a rheumatic disease have elevated blood sedimentation rates and antinuclear antibodies. Furthermore, capillary nail fold abnormalities can frequently be found as described above.
How is Raynaud's phenomenon treated?
Management of Raynaud's phenomenon involves protecting the fingers and the toes from cold, trauma, and infection. Medications that can aggravate blood vessel spasm should be avoided by patients with RP. In patients with persistent symptoms, medications which dilate the blood vessels can be administered.
Patients with Raynaud's phenomenon who have no symptoms other than the color changes of extremities may require only measures to prevent complications. Prevention measures are important in primary and secondary RP regardless of the severity. Simple initial care involves keeping the body warm, especially the extremities. Warm clothing in colder environments is essential. Cotton gloves can be helpful while searching the freezer. Room temperatures should not be too cool. Rubber gloves protect the hands and prevent cooling while dish washing. Barefoot walking should be minimized. Compression of the blood vessels by tight-fitting wrist bands, rings or foot wear should be avoided.
Patients should guard their hands and feet from direct trauma and wounds. Any wounds or infections should be treated early to prevent more serious infections. Avoiding emotional stresses and tools that vibrate the hand may reduce the frequency of attacks. Biofeedback can also help to decrease the severity and frequency of RP in some patients.
Direct and indirect smoking should be avoided in patients with RP. The chemicals in tobacco smoke can cause blood vessel constriction and lead to hardening of the arteries, which can further impair oxygen supply to the extremities.
Care of the nails must be done carefully to avoid injuring sensitive toes and fingertips. Ulcers on the tips of the digits should be monitored closely by the doctor. These can become infected. Gently applied finger splints are used to protect ulcerated areas. Ointments that open the blood vessels (nitroglycerin ointment) are sometimes used on the sides of severely affected digits to allow increased blood supply and healing.
Medications which can aggravate symptoms of RP by leading to increased blood vessel spasm include over-the-counter cold and weight- control preparations, such as pseudoephedrine (Actifed, Chlor-trimeton, Cotylenol, Sudafed). "Beta-blockers," medicines used for high blood pressure and heart disease, can also worsen RP. These include atenolol (Tenorectic), metoprolol (Lopressor), nadolol (Corgard) and propranolol (Inderal).
Patients with persistent or bothersome symptoms may be helped by taking oral medications that open (dilate) blood vessels. These include calcium antagonists, such as diltiazem (Cardizem, Dilacor), nicardipine (Cardene), nifedipine (Procardia), and other medicines used in blood pressure treatment, such as methyldopa (Aldomet) and minipress (Prazocin). Recent research has shown that the blood pressure drug losartan (Cozaar, Hyzaar) can reduce the severity of episodes of RP even more than nifedipine.
Medications that "thin" the blood, such as low doses of aspirin or dipyridamole (Persantine) are sometimes helpful.
Some patients with persistent symptoms can benefit by adding a medication called toxifylline (Trental) which makes the red blood cells more pliable, thereby improving circulation.
Severe RP can lead to gangrene and the loss of digits. In rare cases of severe disease, nerve surgery called "sympathectomy" is sometimes considered. In order to prevent blood vessel spasming, the nerves that stimulate the constriction of the vessels (sympathetic nerves) are surgically interrupted. Usually this is performed during an operation that is localized to the sides of the base of the fingers at the hand. Through small incisions the tiny nerves around the blood vessels are stripped away. This procedure is referred to as a digital sympathectomy. Research
Researchers have reported finding a substantial genetic (inherited) contribution both to the symptoms of RP and to the associated blood vessel changes of patients with Raynaud's phenomenon.
Other researchers are studying nitric oxide and its potential relationship to Raynaud's phenomenon. A gel is being studied which might promote local production of nitric oxide in involved digits. The local nitric oxide, it seems, may open the blood vessels and improve the impaired circulation. - Raynaud's phenomenon is characterized by a pale-blue-red sequence of color changes of the digits, most commonly after exposure to cold.
- Raynaud's phenomenon occur because of spasm of blood vessel.
- The cause of Raynaud's phenomenon is unknown, although abnormal nerve control of blood vessel diameter and nerve sensitivity to cold are suspected.
- Symptoms of Raynaud's phenomenon depend on the severity, frequency, and duration of the blood vessel spasm.
- There is no blood test for diagnosing Raynaud's phenomenon.
- Treatment of Raynaud's phenomenon involves protection of the digits, medications, and avoiding emotional stresses, smoking, cold temperature, and tools that vibrate the hands.
For further information about Raynaud's phenomenon, please visit the following site:
The Arthritis Foundation (http://www.arthritis.org)
Or you can write to:
The Arthritis Foundation
P.O. Box 19000
Atlanta, Georgia 30326
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