MEDICAL DICTIONARY
Serotonin reuptake inhibitor, selective: A selective serotonin reuptake inhibitor (SSRI) is one of the commonly prescribed drugs for treating depression .
SSRIs affect the chemicals that nerves in the brain use to send messages to one another. These chemical messengers, called neurotransmitters, are released by one nerve and taken up by other nerves. Neurotransmitters that are not taken up by other nerves are taken up by the same nerves that released them. This process is termed "reuptake." SSRIs work by inhibiting the reuptake of serotonin, an action which allows more serotonin to be available to be taken up by other nerves.
The most commonly prescribed SSRIs as of 1999 were paroxetine (brandname Paxil), fluoxetine (brandname Prozac) and sertraline (brandname Zoloft).
All three of these SSRIs appear equally efficacious, according to a 1999 study. The rate of patients switching from one class of drugs to another did not differ among the drug classes studied and there was no significant difference in the proportion of patients who switched from an SSRI to another SSRI (or another type of antidepressant), regardless of whether paroxetine (Paxil), fluoxetine (Prozac) or sertraline (Zoloft) was the initial therapy. These three SSRIs therefore are "equivalent in their effectiveness" but they "...are not interchangeable, because patients who discontinue one SSRI for lack of tolerability or response can generally be treated effectively with another." (Reference: J Clin Psychiatry 1999;60:574-579.)
|
DISCLAIMER:
Information on this site is provided for informational
purposes and is not meant to substitute for the advice
provided by your own physician or other medical professional.
You should not use the information contained herein
for diagnosing or treating a health problem or disease,
or prescribing any medication. You should read carefully
all product packaging. Not all Canadian drugs, Canada
prescription and Canadian prescription medicine is available
at discount Canadian on line pharmacies. If you have
or suspect that you have a medical problem, promptly
contact your health care provider. Information and statements
regarding diet supplements have not been evaluated by
Health Canada and are not intended to diagnose, treat,
cure, or prevent any disease. All trade and service
marks mentioned on this site are recognized as belonging
to their respective owners.
|
|
|
|
