MEDICAL DICTIONARY
Pregnancy-associated plasma protein A: Abbreviated as PAPPA or PAPP-A. A large zinc-binding protein that acts as an enzyme , specifically a metallopeptidase. The gene for PAPPA is in chromosome band 9q33.1. PAPPA has been used in prenatal genetic screening and studies of atherosclerosis . Women with low blood levels of PAPPA at 8 to 14 weeks of gestation have an increased risk of intrauterine growth restriction , trisomy 21, premature delivery, preeclampsia , and stillbirth . PAPPA is present in unstable atherosclerotic plaques, and circulating levels are elevated in acute coronary syndromes which may reflect the instability of the plaques. PAPPA may be a marker of unstable angina and acute myocardial infarction (heart attack).
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