MEDICAL DICTIONARY
PPAR: Abbreviation for peroxisome proliferator-activated receptor .
There are 3 known subtypes of PPARs -- PPAR-alpha, PPAR-delta, and PPAR-gamma. The PPARs are members of the nuclear hormone receptor subfamily of transcription factors.
The gene for PPAR-gamma is in chromosome band 3p25. It regulates the development of adipocytes (fat cells).
PPAR-gamma also influences the prenatal survival of dizygotic (nonidentical) twins. Twins with the same type of PPAR-gamma may develop at the same pace. However, when the twins are carrying different versions of PPAR-gamma, one twin may develop at the expense of the other.
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