MEDICAL DICTIONARY
Genes, breast cancer susceptibility: Inherited factors that predispose to breast cancer. Put otherwise, these genes make one more susceptible to the disease and so increase the risk of developing breast cancer . Two of these genes, BRCA1 and BRCA2, have been identified (and prominently publicized). Several other genes (those for the Li-Fraumeni syndrome, Cowden disease, Muir-Torre syndrome, and ataxia-telangiectasia) are also known to predispose to breast cancer. However, since all of these known breast cancer susceptibility genes together do not account for more than a minor fraction (1/5th at most) of breast cancer that clusters in families, it is clear that more breast cancer genes remain to be discovered. See related entries to:
BRCA1; BRCA2; Breast cancer, familial.
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