MEDICAL DICTIONARY
Ferritin: The major iron storage protein . The blood level of ferritin serves as an indicator of the amount of iron stored in the body.
Ferritin has the shape of a hollow sphere that permits the entry of a variable amount of iron for storage (as ferric hydroxide phosphate complexes). Liver and spleen ferritin consists of 24 subunits of 2 kinds, the heavy and the light subunit. The genes that encode the light and heavy chains are on different chromosomes . The light chain genes are in chromosome region 19q13.3-q13.4 while those for the heavy chain are in chromosome region 11q12-q13.
Mutations in the ferritin light chain are responsible for a disease called the hyperferritinemia-cataract syndrome characterized by cataracts (opacities in the lens of the eye) and high levels of ferritin in the blood.
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