MEDICAL DICTIONARY
Familial eosinophilia: An autosomal dominant condition characterized by an abnormally high level of eosinophils in the blood. Despite the prolonged eosinophilia , there may be no symptoms. The gene for familial eosinophilia, called EOS, has been mapped to chromosome region 5q31-33 containing the cytokine gene cluster which includes the genes for interleukin-3 (IL-3), interleukin-5 (IL-5), and granulocyte colony-stimulating factor (G-CSF), and all of which are thought play roles in the development, proliferation, and activation of eosinophils.
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