MEDICAL DICTIONARY
Elliptocytosis: Hematologic disorder characterized by elliptically shaped red blood cells (elliptocytosis) with variable breakup of red cells (hemolysis) and varying degrees of anemia . Inherited as a dominant trait. Due to mutation (change) in one of the genes encoding proteins of the red cell membrane skeleton.
In 1956 Newton Morton brilliantly showed that there were at least 2 forms of elliptocytosis, one form linked to the Rh blood group and another form not linked to Rh (now known to be on chromosome 1). The Rh-linked form, called EL1, in is due to a mutation in erythrocyte membrane protein 4.1. Forms of elliptocytosis not linked to Rh are due to mutations in the alpha-spectrin gene, the beta-spectrin gene, or the band 3 gene. The linkage between elliptocytosis and Rh was one of the first autosomal linkages discovered.
|
DISCLAIMER:
Information on this site is provided for informational
purposes and is not meant to substitute for the advice
provided by your own physician or other medical professional.
You should not use the information contained herein
for diagnosing or treating a health problem or disease,
or prescribing any medication. You should read carefully
all product packaging. Not all Canadian drugs, Canada
prescription and Canadian prescription medicine is available
at discount Canadian on line pharmacies. If you have
or suspect that you have a medical problem, promptly
contact your health care provider. Information and statements
regarding diet supplements have not been evaluated by
Health Canada and are not intended to diagnose, treat,
cure, or prevent any disease. All trade and service
marks mentioned on this site are recognized as belonging
to their respective owners.
|
|
|
|
