MEDICAL DICTIONARY
Doxorubicin cardiomyopathy: Heart disease due to the drug doxorubicin (brand name:Adriamycin), a potent broad-spectrum antitumor agent effective in treating a variety of cancers including solid tumors and leukemia . Unfortunately, its clinical use is limited by dose-dependent cardiac side effects that lead to degenerative cardiomyopathy , congestive heart failure , and death. In addition, some adult patients treated with the drug when they were children later develop dilated cardiomyopathy .
Endocardial biopsies from patients undergoing doxorubicin therapy reveal a disruption of myofibrils, impairment of microtubule assembly, and a swelling of the endoplasmic reticulum. Doxorubicin cardiotoxicity is also characterized by a dose-dependent decline in mitochondrial oxidative phosphorylation and a decrease in high-energy phosphate pools.
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